Auflistung nach Schlagwort "protein microarray"

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  • A Chemical Chaperone Restores Connexin 26 Mutant Activity 
    Wang, Dahua; Wang, Hongling; Fan, Lu; Ludwig, Tobias; Wegner, Andre; Stahl, Frank; Harre, Jennifer; Warnecke, Athanasia; Zeilinger, Carsten (Washington, DC : ACS Publications, 2023)
    Mutations in connexin 26 (Cx26) cause hearing disorders of a varying degree. Herein, to identify compounds capable of restoring the function of mutated Cx26, a novel miniaturized microarray-based screening system was ...
  • Multiformin-Type Azaphilones Prevent SARS-CoV-2 Binding to ACE2 Receptor 
    Jansen-Olliges, Linda; Chatterjee, Shambhabi; Jia, Lili; Stahl, Frank; Bär, Christian; Stadler, Marc; Surup, Frank; Zeilinger, Carsten (Basel : MDPI, 2023)
    Protein microarray screenings identified fungal natural products from the azaphilone family as potent inhibitors of SARS-CoV-2 spike protein binding to host ACE2 receptors. Cohaerin F, as the most potent substance from the ...
  • Multiplexed heat shock protein microarray as a screening platform for the selection of novel drug compounds 
    Schax, Emilia; Neunaber, Janek; Stahl, Frank; Walter, Johanna-Gabriela; Scheper, Thomas; Eichner, Simone; Kirschning, Andreas; Zeilinger, Carsten (Dundee : Dundee Science Press Ltd, 2014-12-22)
    In diseases such as cancer, Alzheimer’s disease or malaria, disease-related proteins take advantage of the heat shock protein (HSP) control system for their own activation or maturation. There is a quest to find inhibitors ...
  • Triiodothyronine Acts as a Smart Influencer on Hsp90 via a Triiodothyronine Binding Site 
    Fan, Lu; Warnecke, Athanasia; Weder, Julia; Preller, Matthias; Zeilinger, Carsten (Basel : Molecular Diversity Preservation International (MDPI), 2022)
    Microarray-based experiments revealed that thyroid hormone triiodothyronine (T3) enhanced the binding of Cy5-labeled ATP on heat shock protein 90 (Hsp90). By molecular docking experiments with T3 on Hsp90, we identified a ...